Article

Exonuclease ISG20 inhibits human cytomegalovirus replication by inducing an innate immune defense signature

2025-02-10

Abstract excerpt

ISG20 is an interferon-regulated protein that exhibits RNase activity thereby inhibiting the replication of a broad spectrum of RNA viruses. By single cell RNA sequencing, we identified ISG20 as an antiviral factor for human cytomegalovirus (HCMV) as it was upregulated in a population of HCMV-resistant cells. In accordance with an antiviral role on herpesviruses, overexpression of ISG20 in primary human fibroblast...

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Literature Corpus work: f0b0ad4c-8052-5ac4-a744-9938d58ea7e9
DOI: 10.1101/2025.02.10.637376

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