Article

G-quadruplex stabilization induces DNA breaks in pericentromeric repetitive DNA sequences in B lymphocytes

2025-05-11

Abstract excerpt

DNA secondary G-quadruplex (G4) structures can impair and even obstruct the DNA replication. Defects in processing G4 structures are associated with replication stress, a common property of both B cell cancers and hyperproliferative premalignant cells. Genome instability arising from replication stress is a hallmark of cancer and strongly contributes to the chromosome rearrangements in B cell cancers. Here, we def...

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Literature Corpus work: 2bd6ba93-ef08-5870-8de6-14e474891b8d
DOI: 10.1101/2025.05.09.653134

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