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Article

G-quadruplexes: a promising target for cancer therapy.

Molecular cancer - 25 Feb 2021

Kosiol Nils, Juranek Stefan, Brossart Peter, Heine Annkristin, Paeschke Katrin

Abstract excerpt

DNA and RNA can fold into a variety of alternative conformations. In recent years, a particular nucleic acid structure was discussed to play a role in malignant transformation and cancer development. This structure is called a G-quadruplex (G4). G4 structure formation can drive genome instability by creating mutations, deletions and stimulating recombination events. The importance of G4 structures in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33632214
DOI: 10.1186/s12943-021-01328-4
PMCID: PMC7905668

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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