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Article

Rare genetic diseases associated with G-quadruplex-induced replication stress.

Communications biology - 13 Apr 2026

Herr Lauren M, Mukhopadhyay Swagata, Anderson Olivia M, Couch Tucker H, Jones Cate M, Brosh Robert M, Rossi Martina

Abstract excerpt

DNA replication stress is incurred by endogenous or environmental challenges to replication fork progression that impede faithful genome duplication. Genomic G-quadruplexes (G4s) are DNA secondary structures that present a substantial barrier for passage of the replisome, and DNA synthesis past these structures requires dynamic remodeling by specialized helicases, translocases, and other G4-binding proteins to...

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Identifiers

PMID: 41975004
DOI: 10.1038/s42003-026-09966-4
PMCID: PMC13076700

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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