Article

G-quadruplexes are a source of vulnerability in <i>BRCA2</i> deficient granule cell progenitors and medulloblastoma

2024-07-22

Abstract excerpt

Biallelic pathogenic variants in the essential DNA repair gene BRCA2 causes Fanconi anemia, complementation group FA-D1. Patients in this group are highly prone to develop embryonal tumors, most commonly medulloblastoma arising from the cerebellar granule cell progenitors (GCPs). GCPs undergo high proliferation in the postnatal cerebellum under SHH activation, but the type of DNA lesions that require the function...

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Literature Corpus work: a8697391-ad4b-5149-a4d5-760b9414120d
DOI: 10.1101/2024.07.20.604431

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