Article
Transcription-associated topoisomerase 2α (TOP2A) activity is a major effector of cytotoxicity induced by G-quadruplex ligands.
eLife - 28 Jun 2021
Bossaert Madeleine, Pipier Angélique, Riou Jean-Francois, Noirot Céline, Nguyên Linh-Trang, Serre Remy-Felix, Bouchez Olivier, Defrancq Eric, Calsou Patrick, Britton Sébastien, Gomez Dennis
Abstract excerpt
G-quadruplexes (G4) are non-canonical DNA structures found in the genome of most species including human. Small molecules stabilizing these structures, called G4 ligands, have been identified and, for some of them, shown to induce cytotoxic DNA double-strand breaks. Through the use of an unbiased genetic approach, we identify here topoisomerase 2α (TOP2A) as a major effector of cytotoxicity induced by two...
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