Article

Mutations of the CHEK2 gene in patients with cancer and their presence in the Latin American population

2016-11-29

Abstract excerpt

<h4>Background: </h4> CHEK2 (Checkpoint Kinase 2) encodes CHK2, a serine/threonine kinase involved in maintaining the G1/S and G2/M checkpoints and repair of double-strand DNA breaks via homologous recombination. Functions of CHK2 include the prevention of damaged cells from going through the cell cycle or proliferating and the maintenance of chromosomal stability. CHEK2 mutations have been reported in a variety...

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Literature Corpus work: 2b73e2f3-924c-519c-8f5f-1ff8822702e8
DOI: 10.12688/f1000research.9932.1

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