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Article

The CHK2 kinase is recurrently mutated and functionally impaired in the germline of pediatric cancer patients.

International journal of cancer - 1 Apr 2023

Wagener Rabea, Walter Carolin, Auer Franziska, Alzoubi Deya, Hauer Julia, Fischer Ute, Varghese Julian, Dugas Martin, Borkhardt Arndt, Brozou Triantafyllia

Abstract excerpt

Predisposing CHEK2 germline variants are associated with various adult-type malignancies, whereas their impact on cancer susceptibility in childhood cancer is unclear. To understand the frequency of germline variants in the CHEK2 gene and their impact on pediatric malignancies, we used whole-exome sequencing to search for CHEK2 variants in the germlines of 418 children diagnosed with cancer in our clinics....

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Identifiers

PMID: 36468172
DOI: 10.1002/ijc.34390

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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