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Clinicopathologic and genetic analysis of invasive breast carcinomas in women with germline CHEK2 variants.

Breast cancer research and treatment - 1 Feb 2024

Schwartz Christopher J, Khorsandi Nikka, Blanco Amie, Mukhtar Rita A, Chen Yunn-Yi, Krings Gregor

Abstract excerpt

PURPOSE: Germline pathogenic variants in checkpoint kinase 2 (CHEK2) are associated with a moderately increased risk of breast cancer (BC). The spectrum of clinicopathologic features and genetics of these tumors has not been fully established. METHODS: We characterized the histopathologic and clinicopathologic features of 44 CHEK2-associated BCs from 35 women, and assessed responses to neoadjuvant chemotherapy. A...

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Identifiers

PMID: 38091153
DOI: 10.1007/s10549-023-07176-8
PMCID: PMC10806021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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