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Article

The CHEK2 gene and inherited breast cancer susceptibility.

Oncogene - 25 Sept 2006

Nevanlinna H, Bartek J

Abstract excerpt

Checkpoint kinase 2 (CHEK2, Chk2) emerges as an important signal transducer of cellular responses to DNA damage and a candidate tumor suppressor whose defects contribute to molecular pathogenesis of diverse types of human malignancies, both sporadic and hereditary. Here, we briefly outline the molecular properties, regulation and physiological role of CHEK2, and review in more detail its defects that predispose...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16998506
DOI: 10.1038/sj.onc.1209877

Genes

CHEK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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The CHEK2 gene and inherited breast cancer susceptibility.PMID 16998506Read ↗

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CHEK2 Germline Variants in Cancer Predisposition: Stalemate Rather than Checkmate.Semantic proximity Read ↗

Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations.Semantic proximity Read ↗

The CHEK2 1100delC mutation identifies families with a hereditary breast and colorectal cancer phenotype.Semantic proximity Read ↗

Chek2 DNA damage response pathway and inherited breast cancer risk.Semantic proximity Read ↗

Is CHEK2 a moderate-risk breast cancer gene or the younger sister of Li-Fraumeni?Semantic proximity Read ↗

A CHEK2 Genetic Variant Contributing to a Substantial Fraction of Familial Breast CancerSemantic proximity Read ↗

Prognostic Significance of CHEK2 Mutation in Progression of Breast CancerSemantic proximity Read ↗

Identification of CHEK2 Germline Mutations in BRCA1/2- and PALB2-Negative Breast and Ovarian Cancer Patients.Semantic proximity Read ↗

Interaction between CHEK2*1100delC and other low-penetrance breast-cancer susceptibility genes: a familial studySemantic proximity Read ↗

Mutations of the CHEK2 gene in patients with cancer and their presence in the Latin American populationSemantic proximity Read ↗

CHEK2 Germ Line Mutations are Lacking among Familial and Sporadic Breast Cancer Patients in RwandaSemantic proximity Read ↗

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