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Identification and analysis of CHEK2 germline mutations in Chinese BRCA1/2-negative breast cancer patients.

Breast cancer research and treatment - 1 May 2018

Fan Zhenhua, Ouyang Tao, Li Jinfeng, Wang Tianfeng, Fan Zhaoqing, Fan Tie, Lin Benyao, Xu Ye, Xie Yuntao

Abstract excerpt

PURPOSE: Cell-cycle-checkpoint kinase 2 (CHEK2) is an important moderate-penetrance breast cancer predisposition gene; however, recurrent CHEK2 mutations found in Caucasian women are very rare in Chinese population. We investigated the mutation spectrum and clinical relevance of CHEK2 germline mutations in Chinese breast cancer patients. METHODS: The entire coding regions and splicing sites of CHEK2 were screened...

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Identifiers

PMID: 29356917
DOI: 10.1007/s10549-018-4673-6

Genes

CHEK2
BRCA1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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