Article
Identification of a novel CHEK2 variant and assessment of its contribution to the risk of breast cancer in French Canadian women.
BMC cancer - 15 Aug 2008
Novak David J, Chen Long Qi, Ghadirian Parviz, Hamel Nancy, Zhang Phil, Rossiny Vanessa, Cardinal Guy, Robidoux André, Tonin Patricia N, Rousseau Francois, Narod Steven A, Foulkes William D
Abstract excerpt
BACKGROUND: BRCA1 and BRCA2 account for the majority of the known familial breast cancer risk, however, the impact of other cancer susceptibility genes largely remains to be elucidated. Checkpoint Kinase 2 (CHEK2) is an important signal transducer of cellular responses to DNA damage, whose defects have been associated with an increase in breast cancer risk. Previous studies have identified low penetrance CHEK2...
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