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Article

Identification of a novel CHEK2 variant and assessment of its contribution to the risk of breast cancer in French Canadian women.

BMC cancer - 15 Aug 2008

Novak David J, Chen Long Qi, Ghadirian Parviz, Hamel Nancy, Zhang Phil, Rossiny Vanessa, Cardinal Guy, Robidoux André, Tonin Patricia N, Rousseau Francois, Narod Steven A, Foulkes William D

Abstract excerpt

BACKGROUND: BRCA1 and BRCA2 account for the majority of the known familial breast cancer risk, however, the impact of other cancer susceptibility genes largely remains to be elucidated. Checkpoint Kinase 2 (CHEK2) is an important signal transducer of cellular responses to DNA damage, whose defect...

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Source

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Identifiers

PMID: 18706089
DOI: 10.1186/1471-2407-8-239
PMCID: PMC2532692

Genes

CHEK2
BRCA1
BRCA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18706089-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of a novel CHEK2 variant and assessment of its contribution to the risk of breast cancer in French Canadian women.PMID 18706089Read ↗

A CHEK2 Genetic Variant Contributing to a Substantial Fraction of Familial Breast CancerSemantic proximity Read ↗

The CHEK2*1100delC allelic variant and risk of breast cancer: screening results from the Breast Cancer Family Registry.Semantic proximity Read ↗

Mutations of the CHEK2 gene in patients with cancer and their presence in the Latin American populationSemantic proximity Read ↗

Germline CHEK2 mutations in Jewish Ashkenazi women at high risk for breast cancer.Semantic proximity Read ↗

The CHEK2 gene and inherited breast cancer susceptibility.Semantic proximity Read ↗

Identification and characterization of novel SNPs in CHEK2 in Ashkenazi Jewish men with prostate cancer.Semantic proximity Read ↗

Linkage disequilibrium mapping of CHEK2: common variation and breast cancer risk.Semantic proximity Read ↗

Current perspectives on CHEK2 mutations in breast cancerSemantic proximity Read ↗

Identification and analysis of CHEK2 germline mutations in Chinese BRCA1/2-negative breast cancer patients.Semantic proximity Read ↗

Missense mutations (p.H371Y, p.D438Y) in gene CHEK2 are associated with breast cancer risk in women of Balochistan origin.Semantic proximity Read ↗

Management of individuals with germline pathogenic/likely pathogenic variants in CHEK2: A clinical practice resource of the American College of Medical Genetics and Genomics (ACMG).Semantic proximity Read ↗

The CHEK2 c.1100delC germline mutation rarely contributes to breast cancer development in the Czech RepublicSemantic proximity Read ↗

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