Article
The CHEK2*1100delC allelic variant and risk of breast cancer: screening results from the Breast Cancer Family Registry.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Feb 2006
Bernstein Jonine L, Teraoka Sharon N, John Esther M, Andrulis Irene L, Knight Julia A, Lapinski Robert, Olson Eric R, Wolitzer Abigail L, Seminara Daniela, Whittemore Alice S, Concannon Patrick
Abstract excerpt
CHEK2, a serine-threonine kinase, is activated in response to agents, such as ionizing radiation, which induce DNA double-strand breaks. Activation of CHEK2 can result in cell cycle checkpoint arrest or apoptosis. One specific variant, CHEK2*1100delC, has been associated with an increased risk of breast cancer. In this population-based study, we screened 2,311 female breast cancer cases and 496 general population...
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