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Article

CHEK2 Germline Variants in Cancer Predisposition: Stalemate Rather than Checkmate.

Cells - 12 Dec 2020

Stolarova Lenka, Kleiblova Petra, Janatova Marketa, Soukupova Jana, Zemankova Petra, Macurek Libor, Kleibl Zdenek

Abstract excerpt

Germline alterations in many genes coding for proteins regulating DNA repair and DNA damage response (DDR) to DNA double-strand breaks (DDSB) have been recognized as pathogenic factors in hereditary cancer predisposition. The ATM-CHEK2-p53 axis has been documented as a backbone for DDR and hypothesized as a barrier against cancer initiation. However, although CHK2 kinase coded by the CHEK2 gene expedites the DDR...

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Identifiers

PMID: 33322746
DOI: 10.3390/cells9122675
PMCID: PMC7763663

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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