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Current perspectives on CHEK2 mutations in breast cancer

1 May 2017

Abstract excerpt

Checkpoint kinase 2 (CHEK2) is a serine/threonine kinase which is activated upon DNA damage and is implicated in pathways that govern DNA repair, cell cycle arrest or apoptosis in response to the initial damage. Loss of kinase function has been correlated with different types of cancer, mainly breast cancer. CHEK2 functionality is affected by different missense or deleterious mutations. CHEK2*1100delC and I157T...

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PMID: 28553140
DOI: 10.2147/bctt.s111394

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Current perspectives on CHEK2 mutations in breast cancerPMID 28553140Read ↗

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