Inborn Errors of Nucleic Acid Sensing and Type I Interferon Signaling Determine Viral Susceptibility in Humans.

Abstract excerpt

The innate immune system relies on nucleic acid (NA) sensors to detect viral infections and trigger type I interferon (IFN-I) responses, which are crucial for antiviral defense. NA pattern recognition receptors detect viral RNA or DNA within various cellular compartments, initiating antiviral signaling pathways. However, inherited deficiencies in these NA sensing mechanisms can result in increased susceptibility...

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