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Integrative multi-omic profiling of adult mouse brain endothelial cells and potential implications in Alzheimer’s disease

1 Nov 2023

Abstract excerpt

The blood-brain barrier (BBB) is primarily manifested by a variety of physiological properties of brain endothelial cells (ECs), but the molecular foundation for these properties remains incompletely clear. Here, we generate a comprehensive molecular atlas of adult brain ECs using acutely purified mouse ECs and integrated multi-omics. Using RNA sequencing (RNA-seq) and proteomics, we identify the transcripts and...

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PMID: 37925638
DOI: 10.1016/j.celrep.2023.113392

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