Article

Integrated multi-omics analysis reveals common and distinct dysregulated pathways for genetic subtypes of Frontotemporal Dementia

2021-02-09

Abstract excerpt

<title>Abstract</title> <p>Understanding the molecular mechanisms underlying frontotemporal dementia (FTD) is essential for the development of successful therapies. Here we integrated transcriptomic and epigenomic analyses of postmortem human brains of FTD patients with mutations in MAPT, GRN and C9orf72 and detected common and distinct dysregulated cellular pathways between patient groups. Our results highlight...

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Literature Corpus work: aacd49dc-4d71-51aa-8e53-0d069cdf0296
DOI: 10.21203/rs.3.rs-153135/v1

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