Article

Zonation-dependent single-endothelial cell transcriptomic changes in the aged brain

2019-10-10

Abstract excerpt

With advances in single-cell genomics, molecular signatures of cells comprising the brain vasculature are revealed in unprecedented detail 1,2 , yet the ageing-associated cell subtype transcriptomic changes which may contribute to neurovascular dysfunction in neurodegenerative diseases 3–7 remain elusive. Here, we performed single-cell transcriptomic profiling of brain endothelial cells (EC) in young adult and a...

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Literature Corpus work: b88e7022-bb89-510b-ba08-4c05be8372aa
DOI: 10.1101/800318

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