Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain

4 Sept 2020

Abstract excerpt

The molecular signatures of cells in the brain have been revealed in unprecedented detail, yet the ageing-associated genome-wide expression changes that may contribute to neurovascular dysfunction in neurodegenerative diseases remain elusive. Here, we report zonation-dependent transcriptomic changes in aged mouse brain endothelial cells (ECs), which prominently implicate altered immune/cytokine signaling in ECs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Barrier Structure and Function Studies
Share to Neuroinflammation and Neurodegeneration Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32887883
DOI: 10.1038/s41467-020-18249-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brainPMID 32887883Read ↗

Zonation-dependent single-endothelial cell transcriptomic changes in the aged brainSemantic proximity Read ↗

Brain endothelial cells are exquisite sensors of age-related circulatory cuesSemantic proximity Read ↗

Inflammatory reprogramming of human brain endothelial cells compromises blood–brain barrier integrity in Alzheimer’s diseaseSemantic proximity Read ↗

Lipid-laden endothelial cells exhibit a transcriptomic signature linked to blood-brain barrier dysfunction, metabolic reprogramming and increased inflammation in the aging brainSemantic proximity Read ↗

Characterization of transcriptomic changes in the neurovascular unit of Alzheimiers transgenic mouse models using digital spatial profilingSemantic proximity Read ↗

High-Dimensional Single-Cell Analysis Reveals Coordinated Age-Dependent Neuroinflammatory Microglia-T cell Circuits in the BrainSemantic proximity Read ↗

Cell-type specific molecular signatures of aging revealed in a brain-wide transcriptomic cell-type atlasSemantic proximity Read ↗

Integrative multi-omic profiling of adult mouse brain endothelial cells and potential implications in Alzheimer’s diseaseSemantic proximity Read ↗

Genome-wide reversal of glial and neurovascular cell transcriptomic aging signatures by GLP-1R agonismSemantic proximity Read ↗

Single-cell multi-region dissection of brain vasculature in Alzheimer’s DiseaseSemantic proximity Read ↗

BBB Dysfunction Defines the Aging Myeloid Landscape Favoring Immune Evasion for Glioma and Alzheimer's DiseaseSemantic proximity Read ↗

ACE2-expressing endothelial cells in aging mouse brainSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.