Article
Mislocalization of centromeric histone H3 variant CENP-A contributes to chromosomal instability (CIN) in human cells.
Oncotarget - 18 Jul 2017
Shrestha Roshan L, Ahn Grace S, Staples Mae I, Sathyan Kizhakke M, Karpova Tatiana S, Foltz Daniel R, Basrai Munira A
Abstract excerpt
Chromosomal instability (CIN) is a hallmark of many cancers and a major contributor to tumorigenesis. Centromere and kinetochore associated proteins such as the evolutionarily conserved centromeric histone H3 variant CENP-A, associate with centromeric DNA for centromere function and chromosomal stability. Stringent regulation of cellular CENP-A levels prevents its mislocalization in yeast and flies to maintain...
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