Back to search

Article

Evolutionary fingerprints of EMT in pancreatic cancers

2023-09-19

Abstract excerpt

Mesenchymal plasticity has been extensively described in advanced and metastatic epithelial cancers; however, its functional role in malignant progression, metastatic dissemination and therapy response is controversial. More importantly, the role of epithelial mesenchymal transition (EMT) and cell plasticity in tumor heterogeneity, clonal selection and clonal evolution is poorly understood. Functionally, our work...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
c387ae14-12a3-569c-9951-facbc58f5476
DOI
10.1101/2023.09.18.558231
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Evolutionary fingerprints of EMT in pancreatic cancersDOI 10.1101/2023.09.18.558231
Evolutionary fingerprints of epithelial-to-mesenchymal transition.Semantic proximity
Epithelial-to-mesenchymal transition drives cancer genomic instabilitySemantic proximity
A Genetically Engineered Human Organoid Model Reveals Distinct Genetic and Epigenetic Barriers of Lineage Plasticity in Early PDAC TransformationSemantic proximity
A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns.Semantic proximity
The Evolutionary History of Metastatic Pancreatic Neuroendocrine Tumours Reveals a Therapy Driven Route to High-Grade TransformationSemantic proximity
Genomic and microenvironmental heterogeneity shaping epithelial-to-mesenchymal trajectories in cancer.Semantic proximity
Single-cell lineage and transcriptome reconstruction of metastatic cancer reveals selection of aggressive hybrid EMT statesSemantic proximity
The many faces of cancer evolutionSemantic proximity
The molecular determinants of phenotypic plasticity in homeostasis and neoplasiaSemantic proximity
Decoding the basis of histological variation in human cancer.Semantic proximity
Update on Epithelial-Mesenchymal Plasticity in Cancer ProgressionSemantic proximity
Behind the Wheel of Epithelial Plasticity in KRAS-Driven CancersSemantic proximity
Select a neighboring publication to make it the new centre.