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The engulfment receptor CED-1/MEGF10 activates the GPCR LAT-1/ADGRL3 for apoptotic cell degradation

2026-06-10

Abstract excerpt

Efferocytosis, the clearance of apoptotic cells, is crucial for tissue homeostasis, inflammation suppression, and repair. While several G protein-coupled receptors (GPCRs) are involved, the broader role of GPCRs in efferocytosis remains unexplored. Through a genome-wide RNAi screen in Caenorhabditis elegans , we identified the adhesion GPCR LAT-1 as a key regulator of apoptotic cell degradation through the promot...

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Literature Corpus work
2b29ef57-aaae-513d-81c8-af0fa2deabc2
DOI
10.64898/2026.06.09.731128
Open publication

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The engulfment receptor CED-1/MEGF10 activates the GPCR LAT-1/ADGRL3 for apoptotic cell degradationDOI 10.64898/2026.06.09.731128
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