Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans.

Nature - 3 Mar 2005

Kinchen Jason M, Cabello Juan, Klingele Doris, Wong Kelvin, Feichtinger Richard, Schnabel Heinke, Schnabel Ralf, Hengartner Michael O

Abstract excerpt

The removal of apoptotic cells is essential for the physiological well being of the organism. In Caenorhabditis elegans, two conserved, partially redundant genetic pathways regulate this process. In the first pathway, the proteins CED-2, CED-5 and CED-12 (mammalian homologues CrkII, Dock180 and ELMO, respectively) function to activate CED-10 (Rac1). In the second group, the candidate receptor CED-1...

Topics

ATP-Binding Cassette Transporters
Actins
Animals
Apoptosis
Apoptosis Regulatory Proteins
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Cytoskeleton
Disorders of Sex Development
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Proteins

Phagocytosis

Phosphoproteins

Signal Transduction

rac GTP-Binding Proteins

Source

Identifiers

PMID: 15744306
DOI: 10.1038/nature03263

Genes

ABCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans.PMID 15744306Read ↗

C. elegans CED-12 acts in the conserved crkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment.Semantic proximity Read ↗

Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12.Semantic proximity Read ↗

PDR-1/hParkin negatively regulates the phagocytosis of apoptotic cell corpses in Caenorhabditis elegans.Semantic proximity Read ↗

Loss of the RhoGAP SRGP-1 promotes the clearance of dead and injured cells in Caenorhabditis elegans.Semantic proximity Read ↗

Engulfment of apoptotic cells in C. elegans is mediated by integrin alpha/SRC signaling.Semantic proximity Read ↗

CED-10/Rac1 regulates endocytic recycling through the RAB-5 GAP TBC-2.Semantic proximity Read ↗

CED-1 is a transmembrane receptor that mediates cell corpse engulfment in C. elegans.Semantic proximity Read ↗

Candidate adaptor protein CED-6 promotes the engulfment of apoptotic cells in C. elegans.Semantic proximity Read ↗

The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway.Semantic proximity Read ↗

The engulfment receptor CED-1/MEGF10 activates the GPCR LAT-1/ADGRL3 for apoptotic cell degradationSemantic proximity Read ↗

Programmed elimination of cells by caspase-independent cell extrusion in C. elegans.Semantic proximity Read ↗

CED-5/CED-12 (DOCK/ELMO) can promote and inhibit F-actin formation via distinct motifs that target different GTPasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.