Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell.

doi:10.1083/jcb.201111053

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Article

Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell.

The Journal of cell biology - 2 Apr 2012

Li Wei, Zou Wei, Yang Yihong, Chai Yongping, Chen Baohui, Cheng Shiya, Tian Dong, Wang Xiaochen, Vale Ronald D, Ou Guangshuo

Abstract excerpt

Apoptotic cell degradation is a fundamental process for organism development, and impaired clearance causes inflammatory or autoimmune disease. Although autophagy genes were reported to be essential for exposing the engulfment signal on apoptotic cells, their roles in phagocytes for apoptotic cell removal are not well understood. In this paper, we develop live-cell imaging techniques to study apoptotic cell...

Topics

Animals
Apoptosis
Autophagy
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Lysosomes
Mutation
Phagocytes
Phagocytosis
Phagosomes
Phenotype
Vesicular Transport Proteins

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Identifiers

PMID: 22451698
DOI: 10.1083/jcb.201111053
PMCID: PMC3317810

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