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Article

PDR-1/hParkin negatively regulates the phagocytosis of apoptotic cell corpses in Caenorhabditis elegans.

Cell death & disease - 13 Mar 2014

Cabello J, Sämann J, Gómez-Orte E, Erazo T, Coppa A, Pujol A, Büssing I, Schulze B, Lizcano J M, Ferrer I, Baumeister R, Dalfo E

Abstract excerpt

Apoptotic cell death is an integral part of cell turnover in many tissues, and proper corpse clearance is vital to maintaining tissue homeostasis in all multicellular organisms. Even in tissues with high cellular turnover, apoptotic cells are rarely seen because of efficient clearance mechanisms in healthy individuals. In Caenorhabditis elegans, two parallel and partly redundant conserved pathways act in cell...

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PMID: 24625979
DOI: 10.1038/cddis.2014.57
PMCID: PMC3973248

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Source receipt: pubmed, retrieved 7 Sept 2026.

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