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Article

Loss of the RhoGAP SRGP-1 promotes the clearance of dead and injured cells in Caenorhabditis elegans.

Nature cell biology - 1 Jan 2011

Neukomm Lukas J, Frei Andreas P, Cabello Juan, Kinchen Jason M, Zaidel-Bar Ronen, Ma Zhong, Haney Lisa B, Hardin Jeff, Ravichandran Kodi S, Moreno Sergio, Hengartner Michael O

Abstract excerpt

Multicellular animals rapidly clear dying cells from their bodies. Many of the pathways that mediate this cell removal are conserved through evolution. Here, we identify srgp-1 as a negative regulator of cell clearance in both Caenorhabditis elegans and mammalian cells. Loss of srgp-1 function results in improved engulfment of apoptotic cells, whereas srgp-1 overexpression inhibits apoptotic cell corpse removal....

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Identifiers

PMID: 21170032
DOI: 10.1038/ncb2138
PMCID: PMC3808961

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Source receipt: pubmed, retrieved 7 Sept 2026.

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