Loss of the RhoGAP SRGP-1 promotes the clearance of dead and injured cells in Caenorhabditis elegans.

doi:10.1038/ncb2138

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Article

Loss of the RhoGAP SRGP-1 promotes the clearance of dead and injured cells in Caenorhabditis elegans.

Nature cell biology - 1 Jan 2011

Neukomm Lukas J, Frei Andreas P, Cabello Juan, Kinchen Jason M, Zaidel-Bar Ronen, Ma Zhong, Haney Lisa B, Hardin Jeff, Ravichandran Kodi S, Moreno Sergio, Hengartner Michael O

Abstract excerpt

Multicellular animals rapidly clear dying cells from their bodies. Many of the pathways that mediate this cell removal are conserved through evolution. Here, we identify srgp-1 as a negative regulator of cell clearance in both Caenorhabditis elegans and mammalian cells. Loss of srgp-1 function results in improved engulfment of apoptotic cells, whereas srgp-1 overexpression inhibits apoptotic cell corpse removal....

Topics

Amino Acid Sequence
Animals
Animals, Genetically Modified
Apoptosis
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Cell Line
GTPase-Activating Proteins
Green Fluorescent Proteins
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microscopy, Fluorescence

Molecular Sequence Data

Mutation

NIH 3T3 Cells

Phagocytosis

Protein Binding

RNA Interference

Sequence Homology, Amino Acid

Source

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Identifiers

PMID: 21170032
DOI: 10.1038/ncb2138
PMCID: PMC3808961

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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