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Article

Structural study of TTR-52 reveals the mechanism by which a bridging molecule mediates apoptotic cell engulfment.

Genes & development - 15 Jun 2012

Kang Yanyong, Zhao Dongfeng, Liang Huanhuan, Liu Bin, Zhang Yan, Liu Qinwen, Wang Xiaochen, Liu Yingfang

Abstract excerpt

During apoptosis, apoptotic cells are removed by professional phagocytes or neighboring engulfing cells either directly through phagocytic receptors or indirectly through bridging molecules that cross-link dying cells to phagocytes. However, how bridging molecules recognize "eat me" signals and phagocytic receptors to mediate engulfment remains unclear. Here, we report the structural and functional studies of...

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Identifiers

PMID: 22713871
DOI: 10.1101/gad.187815.112
PMCID: PMC3387661

Genes

TTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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