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Article

Programmed elimination of cells by caspase-independent cell extrusion in C. elegans.

Nature - 9 Aug 2012

Denning Daniel P, Hatch Victoria, Horvitz H Robert

Abstract excerpt

The elimination of unnecessary or defective cells from metazoans occurs during normal development and tissue homeostasis, as well as in response to infection or cellular damage. Although many cells are removed through caspase-mediated apoptosis followed by phagocytosis by engulfing cells, other mechanisms of cell elimination occur, including the extrusion of cells from epithelia through a poorly understood,...

Topics

Animals
Apoptosis
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Carrier Proteins
Caspases
Cell Adhesion Molecules
Cell Shape
Embryo, Nonmammalian
Embryonic Development
Endocytosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multiprotein Complexes

Mutation

Protein Serine-Threonine Kinases

Source

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Identifiers

PMID: 22801495
DOI: 10.1038/nature11240
PMCID: PMC3416925

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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