Back to search

Article

A Modular Platform for the Optogenetic Control of Small GTPase Activity in Living Cells Reveals Long-Range RhoA Signaling

2025-09-07

Abstract excerpt

Small GTPases are critical regulators of cellular processes, such as cell migration, and comprise a family of over 167 proteins in the human genome. Importantly, the location-dependent regulation of small GTPase activity is integral to coordinating cellular signaling. Currently, there are no generalizable methods for directly controlling the activity of these signaling enzymes with subcellular precision. To addres...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
5baf910d-9771-5f19-8e01-73f5ee1fcd8c
DOI
10.1101/2025.09.07.674731
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A Modular Platform for the Optogenetic Control of Small GTPase Activity in Living Cells Reveals Long-Range RhoA SignalingDOI 10.1101/2025.09.07.674731
Long range mutual activation establishes Rho and Rac polarity during cell migrationSemantic proximity
Spatial Organization of Rho GTPase signaling by RhoGEF/RhoGAP proteinsSemantic proximity
An apicobasal gradient of Rac activity determines protrusion form and position.Semantic proximity
The novel Rho-family GTPase rif regulates coordinated actin-based membrane rearrangements.Semantic proximity
The WASP and WAVE family proteinsSemantic proximity
Single Living Cell Analysis Decodes Dynamical Signaling Patterns Triggering Different Phenotypes of Cell Migration.Semantic proximity
Direct activation of the Ras-Akt network mediates polarity and organizes protrusions in human neutrophil migrationSemantic proximity
Targeting Rho GTPase Signaling Networks in CancerSemantic proximity
Paxillin mediates sensing of physical cues and regulates directional cell motility by controlling lamellipodia positioning.Semantic proximity
PIP5K-Ras bistability triggers plasma membrane symmetry breaking to define cellular polarity and regulate migrationSemantic proximity
Role of Rho GTPases in stem cell regulationSemantic proximity
Rho family GTPases.Semantic proximity
Select a neighboring publication to make it the new centre.