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Article

PIP₃-dependent macropinocytosis is incompatible with chemotaxis.

The Journal of cell biology - 17 Feb 2014

Veltman Douwe M, Lemieux Michael G, Knecht David A, Insall Robert H

Abstract excerpt

In eukaryotic chemotaxis, the mechanisms connecting external signals to the motile apparatus remain unclear. The role of the lipid phosphatidylinositol 3,4,5-trisphosphate (PIP₃) has been particularly controversial. PIP₃ has many cellular roles, notably in growth control and macropinocytosis as well as cell motility. Here we show that PIP₃ is not only unnecessary for Dictyostelium discoideum to migrate toward...

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Identifiers

PMID: 24535823
DOI: 10.1083/jcb.201309081
PMCID: PMC3926956

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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