Article

Phosphoinositide lipids have bidirectional and spatially distinct roles in filopodial dynamics

2025-10-14

Abstract excerpt

Neural circuits are assembled by filopodia, dynamic actin-rich protrusions that connect environment sensing with structural changes. Using rapid timelapse imaging and acute pharmacological perturbation in Xenopus laevis retinal ganglion cells, we reveal that phosphoinositide lipid conversions impose spatially distinct control over filopodial dynamics. The class I phosphoinositide 3-kinase (PI3K) inhibitor alpelis...

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Literature Corpus work: bbd6f4b6-d3d8-5ab9-ab1a-5bacbd7a082e
DOI: 10.1101/2025.10.13.681625

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