Article
Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway.
Science (New York, N.Y.) - 31 Aug 2018
Bugaj L J, Sabnis A J, Mitchell A, Garbarino J E, Toettcher J E, Bivona T G, Lim W A
Abstract excerpt
The Ras-Erk (extracellular signal-regulated kinase) pathway encodes information in its dynamics; the duration and frequency of Erk activity can specify distinct cell fates. To enable dynamic encoding, temporal information must be accurately transmitted from the plasma membrane to the nucleus. We used optogenetic profiling to show that both oncogenic B-Raf mutations and B-Raf inhibitors can cause corruption of...
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