Article

Mechanism of activation of an ancestral TEC kinase by PIP <sub>3</sub>

2025-05-27

Abstract excerpt

The TEC kinases are a family of five paralogous mammalian genes that play crucial roles in cell growth, proliferation and differentiation, particularly in immune cells. The recruitment and activation of the TEC kinases depend on the generation of the lipid second messenger, PIP 3 , in the plasma membrane. However, the mechanisms by which PIP 3 activates the TEC kinases are not well understood. We have elucidated...

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Identifiers and source

Literature Corpus work: 7e725351-7297-54f8-aa02-8ca7bf9ae02e
DOI: 10.1101/2025.05.22.653117

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