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Article

Symmetry-breaking polarization driven by a Cdc42p GEF-PAK complex.

Current biology : CB - 25 Nov 2008

Kozubowski Lukasz, Saito Koji, Johnson Jayme M, Howell Audrey S, Zyla Trevin R, Lew Daniel J

Abstract excerpt

BACKGROUND: In 1952, Alan Turing suggested that spatial patterns could arise from homogeneous starting conditions by feedback amplification of stochastic fluctuations. One example of such self-organization, called symmetry breaking, involves spontaneous cell polarization in the absence of spatial cues. The conserved GTPase Cdc42p is essential for both guided and spontaneous polarization, and in budding yeast...

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Share to Adaptor Proteins, Signal Transducing
Share to cdc42 GTP-Binding Protein, Saccharomyces cerevisiae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Guanine Nucleotide Exchange Factors

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Source

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Identifiers

PMID: 19013066
DOI: 10.1016/j.cub.2008.09.060
PMCID: PMC2803100

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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