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Article

Self-organization of the phosphatidylinositol lipids signaling system for random cell migration.

Proceedings of the National Academy of Sciences of the United States of America - 6 Jul 2010

Arai Yoshiyuki, Shibata Tatsuo, Matsuoka Satomi, Sato Masayuki J, Yanagida Toshio, Ueda Masahiro

Abstract excerpt

Phosphatidylinositol (PtdIns) lipids have been identified as key signaling mediators for random cell migration as well as chemoattractant-induced directional migration. However, how the PtdIns lipids are organized spatiotemporally to regulate cellular motility and polarity remains to be clarified. Here, we found that self-organized waves of PtdIns 3,4,5-trisphosphate [PtdIns(3,4,5)P(3)] are generated...

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Identifiers

PMID: 20562345
DOI: 10.1073/pnas.0908278107
PMCID: PMC2901478

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PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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