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Article

Mechanochemical feedback underlies coexistence of qualitatively distinct cell polarity patterns within diverse cell populations.

Proceedings of the National Academy of Sciences of the United States of America - 11 Jul 2017

Park JinSeok, Holmes William R, Lee Sung Hoon, Kim Hong-Nam, Kim Deok-Ho, Kwak Moon Kyu, Wang Chiaochun Joanne, Edelstein-Keshet Leah, Levchenko Andre

Abstract excerpt

Cell polarization and directional cell migration can display random, persistent, and oscillatory dynamic patterns. However, it is not clear whether these polarity patterns can be explained by the same underlying regulatory mechanism. Here, we show that random, persistent, and oscillatory migration accompanied by polarization can simultaneously occur in populations of melanoma cells derived from tumors with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28655842
DOI: 10.1073/pnas.1700054114
PMCID: PMC5514712

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