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Article

Dynamic remodeling of host membranes by self-organizing bacterial effectors.

Science (New York, N.Y.) - 28 May 2021

Hsieh Ting-Sung, Lopez Victor A, Black Miles H, Osinski Adam, Pawłowski Krzysztof, Tomchick Diana R, Liou Jen, Tagliabracci Vincent S

Abstract excerpt

During infection, intracellular bacterial pathogens translocate a variety of effectors into host cells that modify host membrane trafficking for their benefit. We found a self-organizing system consisting of a bacterial phosphoinositide kinase and its opposing phosphatase that formed spatiotemporal patterns, including traveling waves, to remodel host cellular membranes. The Legionella effector MavQ, a...

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Identifiers

PMID: 33927055
DOI: 10.1126/science.aay8118
PMCID: PMC8543759

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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