Article
Evolutionary dynamics of neoantigens in growing tumors.
Nature genetics - 1 Oct 2020
Lakatos Eszter, Williams Marc J, Schenck Ryan O, Cross William C H, Househam Jacob, Zapata Luis, Werner Benjamin, Gatenbee Chandler, Robertson-Tessi Mark, Barnes Chris P, Anderson Alexander R A, Sottoriva Andrea, Graham Trevor A
Abstract excerpt
Cancers accumulate mutations that lead to neoantigens, novel peptides that elicit an immune response, and consequently undergo evolutionary selection. Here we establish how negative selection shapes the clonality of neoantigens in a growing cancer by constructing a mathematical model of neoantigen evolution. The model predicts that, without immune escape, tumor neoantigens are either clonal or at low frequency;...
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