Evolutionary dynamics of neoantigens in growing tumours

Abstract excerpt

<h4>ABSTRACT</h4> Cancer evolution is driven by the acquisition of somatic mutations that provide cells with a beneficial phenotype in a changing microenvironment. However, mutations that give rise to neoantigens, novel cancer–specific peptides that elicit an immune response, are likely to be disadvantageous. Here we show how the clonal structure and immunogenotype of growing tumours is shaped by negative selecti...

Topics

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• Antigens, Neoplasm
• Clonal Evolution
• Exome
• Exome Sequencing
• Immunity, Cellular
• Lymphocytes, Tumor-Infiltrating
• Models, Theoretical
• Selection, Genetic

Identifiers and source

Literature Corpus work

c7a1ea16-b50d-5217-a929-0b00e1f41e61

DOI

10.1101/536433