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Article

Influence of T Cell-Mediated Immune Surveillance on Somatic Mutation Occurrences in Melanoma.

Frontiers in immunology - 1 Jan 2021

Jiang Chongming, Schaafsma Evelien, Hong Wei, Zhao Yanding, Zhu Ken, Chao Cheng-Chi, Cheng Chao

Abstract excerpt

Background: Neoantigens are presented on the cancer cell surface by peptide-restricted human leukocyte antigen (HLA) proteins and can subsequently activate cognate T cells. It has been hypothesized that the observed somatic mutations in tumors are shaped by immunosurveillance. Methods: We investigated all somatic mutations identified in The Cancer Genome Atlas (TCGA) Skin Cutaneous Melanoma (SKCM) samples. By...

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Share to Antigens, Neoplasm
Share to Histocompatibility Antigens Class I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35111147
DOI: 10.3389/fimmu.2021.703821
PMCID: PMC8801458

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