Article

Integrated modeling to implicate evolving neoantigen-T cell interplays and immunotherapy efficacy in tumors

2022-11-28

Abstract excerpt

Immunotherapies have revolutionized cancer treatment modalities; however, predicting clinical response accurately and reliably remains challenging. Neoantigen load is considered as a fundamental genetic determinant of therapeutic response. However, only a few predicted neoantigens are highly immunogenetic, with little focus on intratumor heterogeneity (ITH) in the neoantigen landscape and its link with different f...

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Literature Corpus work: 56f55f7f-014f-55d4-b8f5-6157c44eee28
DOI: 10.21203/rs.3.rs-2298973/v1

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