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Article

Visualizing a protonated RNA state that modulates microRNA-21 maturation.

Nature chemical biology - 1 Jan 2021

Baisden Jared T, Boyer Joshua A, Zhao Bo, Hammond Scott M, Zhang Qi

Abstract excerpt

MicroRNAs are evolutionarily conserved small, noncoding RNAs that regulate diverse biological processes. Due to their essential regulatory roles, microRNA biogenesis is tightly regulated, where protein factors are often found to interact with specific primary and precursor microRNAs for regulation. Here, using NMR relaxation dispersion spectroscopy and mutagenesis, we reveal that the precursor of oncogenic...

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PMID: 33106660
DOI: 10.1038/s41589-020-00667-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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