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Immune receptor LAG3 regulates microglia function during Alzheimer’s disease

2026-05-12

Abstract excerpt

Alzheimer’s Disease (AD) remains the leading cause of dementia globally, yet the exact etiology is not well defined and effective treatments remain unavailable. Here, we report that deletion of the immune checkpoint receptor lymphocyte activation gene 3 ( Lag3 ) in a familial AD mouse model, 5xFAD + , can rescue molecular, cellular and behavioral phenotypes of neurodegeneration. Specifically, we demonstrate that...

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Identifiers and source

Literature Corpus work
2aa61137-8215-5619-b391-28434c79c2d7
DOI
10.64898/2026.05.08.723911
Open publication

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Immune receptor LAG3 regulates microglia function during Alzheimer’s diseaseDOI 10.64898/2026.05.08.723911
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