Article

5xFAD-NSG mice: a preclinical Alzheimer model for human cell therapy studies

2026-03-05

Abstract excerpt

<h4>Abstract/Summary</h4> Cellular therapies are one class of medicine being developed to treat Alzheimer’s disease (AD), a neurodegenerative disease with memory loss, aberrant protein accumulation in the brain, and neuroinflammation. One challenge for development of human cell therapeutics is to have preclinical animal models that allow the use of human cells without immune-mediated rejection of those cells. The...

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Literature Corpus work: fbc617d1-0af1-5cf7-9623-4434eb3b0243
DOI: 10.64898/2026.03.03.709048

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