Article
Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer's-induced retinal vasculopathy by limiting Clec7a/Galectin-3+ neurodegenerative microglia.
Acta neuropathologica communications - 8 Sept 2022
Shi Haoshen, Yin Zhuoran, Koronyo Yosef, Fuchs Dieu-Trang, Sheyn Julia, Davis Miyah R, Wilson Jered W, Margeta Milica A, Pitts Kristen M, Herron Shawn, Ikezu Seiko, Ikezu Tsuneya, Graham Stuart L, Gupta Vivek K, Black Keith L, Mirzaei Mehdi, Butovsky Oleg, Koronyo-Hamaoui Maya
Abstract excerpt
Single cell RNA sequencing studies identified novel neurodegeneration-associated microglial (MGnD/DAM) subtypes activated around cerebral amyloid plaques. Micro-RNA (miR)-155 of the TREM2-APOE pathway was shown to be a key transcriptional regulator of MGnD microglial phenotype. Despite growing interest in studying manifestations of Alzheimer's disease (AD) in the retina, a CNS organ accessible to noninvasive...
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