Article

Ifit2 regulates murine-coronavirus spread to the spinal cord white matter and its associated myelin pathology

2022-06-07

Abstract excerpt

Ifit2, an interferon-induced protein with tetratricopeptide repeats 2, plays a critical role in restricting neurotropic murine β-coronavirus RSA59 infection. RSA59 intracranial injection of Ifit2 deficient (-/-) compared to wild type (WT) mice results in impaired acute microglial activation, associated with reduced CX3CR1 expression, which consecutively limits migration of peripheral lymphocytes into the brain, le...

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Literature Corpus work: 2a87453d-6b35-5e02-83f2-6171954df295
DOI: 10.1101/2022.06.06.494972

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