Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transgenic CCL2 Expression in the Central Nervous System Results in a Dysregulated Immune Response and Enhanced Lethality after Coronavirus Infection

26 Dec 2012

Abstract excerpt

Chemokine (C-C motif) ligand 2 (CCL2), a chemoattractant for macrophages, T cells, and cells expressing CCR2, is upregulated during acute and chronic inflammation. CCL2 has been implicated in both proinflammatory and anti-inflammatory responses and has been suggested as a target for therapy in some inflammatory disorders. To examine the role of CCL2 during virus infection, we infected mice transgenically...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemokine receptors and signaling
Share to Immune cells in cancer
Share to Neuroinflammation and Neurodegeneration Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23269787
DOI: 10.1128/jvi.03089-12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transgenic CCL2 Expression in the Central Nervous System Results in a Dysregulated Immune Response and Enhanced Lethality after Coronavirus InfectionPMID 23269787Read ↗

Mouse Adapted SARS-CoV-2 (MA10) Viral Infection Induces Neuroinflammation in Standard Laboratory MiceSemantic proximity Read ↗

Cellular reservoirs for coronavirus infection of the brain in beta2-microglobulin knockout mice.Semantic proximity Read ↗

Experimental autoimmune encephalomyelitis (EAE) in CCR2(-/-) mice: susceptibility in multiple strains.Semantic proximity Read ↗

Monocyte Chemoattractant Protein‐1 (CCL2) in Inflammatory Disease and Adaptive Immunity: Therapeutic Opportunities and ControversiesSemantic proximity Read ↗

CCL2 Overexpression in the Brain Promotes Glial Activation and Accelerates Tau Pathology in a Mouse Model of Tauopathy.Semantic proximity Read ↗

CCL2/MCP-1 controls parasite burden, cell infiltration, and mononuclear activation during acute Trypanosoma cruzi infection.Semantic proximity Read ↗

Trem2 deficiency impairs recovery and phagocytosis by dysregulating myeloid gene expression during virus induced demyelinationSemantic proximity Read ↗

Mouse Hepatitis Virus Infection of the Central Nervous System: Chemokine-Mediated Regulation of Host Defense and DiseaseSemantic proximity Read ↗

A novel role for C-C motif chemokine receptor 2 during infection with hypervirulent Mycobacterium tuberculosis.Semantic proximity Read ↗

CCRL2 regulates M1/M2 polarization during EAE recovery phaseSemantic proximity Read ↗

Mice overexpressing chemokine ligand 2 (CCL2) in astrocytes display enhanced nociceptive responses.Semantic proximity Read ↗

Astrocyte- and endothelial-targeted CCL2 conditional knockout mice: critical tools for studying the pathogenesis of neuroinflammation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.