Article

BATF2 is a regulator of interferon-γ signaling in astrocytes during neuroinflammation

2024-07-16

Abstract excerpt

<h4>Summary</h4> Astrocytic interferon (IFN)γ signaling is associated with a reduction in neuroinflammation. We have previously shown that the benefits of astrocytic IFNγ arise from a variety of mechanisms; however, downstream effectors responsible for regulating this protection are unknown. We address this by identifying a specific transcription factor that may play a key role in modulating the consequences of I...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0664e0a1-83b3-5405-91ad-aa0e17e152fc
DOI: 10.1101/2024.07.10.602938

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

BATF2 is a regulator of interferon-γ signaling in astrocytes during neuroinflammationDOI 10.1101/2024.07.10.602938Read

Loss of the Immunomodulatory Transcription Factor BATF2 in Humans Is Associated with a Neurological Phenotype.Semantic proximity Read

IFN-induced protein with tetratricopeptide repeats 2 (Ifit2) limits autoimmune inflammation by regulating myeloid cell activation and metabolic activitySemantic proximity Read

Integrated transcriptomic profiling reveals a STING-mediated Type II Interferon signature in SOD1-mutant amyotrophic lateral sclerosis modelsSemantic proximity Read

ADAR1 suppression causes interferon signaling and transposable element transcript accumulation in human astrocytesSemantic proximity Read

Ifi27l2a acts as a cytokine that promotes a pro-inflammatory phenotype in microglia and enhances neuroinflammationSemantic proximity Read

Transcription initiation profiling defines the regulatory logic of astrocyte gene regulationSemantic proximity Read

Astrocytes, an active player in Aicardi-Goutières syndrome.Semantic proximity Read

The Neurogenic Potential of Astrocytes Is Regulated by Inflammatory Signals.Semantic proximity Read

Activation of interferon signaling pathways in spinal cord astrocytes from an ALS mouse modelSemantic proximity Read

The antiviral Interferon pathway drives astrocyte aging and motor declineSemantic proximity Read

IFNγ and proinflammatory cytokines cooperatively license astrocytes to support antigen-dependent CD4+ T cell restimulationSemantic proximity Read

Ifit2 regulates murine-coronavirus spread to the spinal cord white matter and its associated myelin pathologySemantic proximity Read