Article

CD40 Signaling Restricts Retrograde Viral Spread and Provides Neuroprotection to Retinal Ganglion Cells in a Murine β-Coronavirus Model of Optic Neuritis

2026-08-21

Abstract excerpt

CD40, a co-stimulatory receptor of the tumor necrosis factor receptor superfamily expressed on microglia and macrophages, is an upstream regulator of innate antiviral defense in coronavirus-induced neuroinflammation, but its specific role in the visual system remains undefined. Here, we demonstrate that CD40 signaling is essential for restricting retrograde axonal transport of the murine β-coronavirus RSA59 from t...

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Literature Corpus work: be8aaf0f-1986-53bf-9854-3333b6385ca8
DOI: 10.64898/2026.08.18.745465

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CD40 Signaling Restricts Retrograde Viral Spread and Provides Neuroprotection to Retinal Ganglion Cells in a Murine β-Coronavirus Model of Optic NeuritisDOI 10.64898/2026.08.18.745465Read

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